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;(21)– [PubMed]; Constantopoulos A, Karpathios T, Nicolaidou P, Maounis F, Matsaniotis N. Lazy-leukocyte syndrome. A case report . The lazy leukocyte syndrome was first described by Miller et al. in in two children with recurrent infection. They had normal humoral and cellular immunity . – LAZY LEUKOCYTE SYNDROME. LAZY LEUKOCYTE SYNDROME. Clinical Synopsis Toggle Dropdown. Inheritance. -? Autosomal dominant new.

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A bonus to all MIMmatch users is the option to sign up for updates on new sgndrome relationships. A severe neutropenia was found. Pathology of chemotaxis and random mobility.

Lazy leukocyte syndrome.

A characteristic abnormality of actin distribution in neutrophils was demonstrated. OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. Looking For More References?


The same abnormality probably leads to impaired deformability of neutrophils so that release of newly formed neutrophils from the bone marrow is reduced. Both random mobility and chemotactic function were defective.

lazy leukocyte syndrome

Transient ‘lazy-leukocyte’ syndrome during infancy. The year-old proposita had neutropenia and an illness suggestive of persistent Epstein-Barr virus infection. We are determined to keep this website freely accessible. Miller knew of 4 other cases. Expert curators review the literature and organize it to facilitate your work. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.

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Autosomal dominant new mutations. Relative to the genetics and the possibility that these cases represent new dominant mutations, parental age data would be of interest.

Mobilization of leukocytes after exercise was defective. Skin window mobilization test and chemotaxis were normal. A new disorder of neutrophil function. Unfortunately, it is not lukocyte to produce. Clinical Synopsis Toggle Dropdown.


We need long-term secure funding to provide you the information that you sundrome at your fingertips. Single cases were reported by Costanopoulos et al. Leukocyte phagocytosis and bactericidal activity were normal. None is familial and no laxy consanguinity is known. The syndrome is distinguished from neutrophil chemotactic deficiencies by the coexistence of defective random motility and peripheral blood neutropenia with normal bone marrow granulocyte reserve.

A poor neutrophil response was obtained upon stimulation with both epinephrine and endotoxin, as well as upon induced inflammation by the Rebuck skin window technique. Bone marrow studies showed normal numbers of mature, morphologically normal neutrophils.