Crossopteryx is a monotypic genus of flowering plants in the Rubiaceae family. The genus contains only one species, viz. Crossopteryx febrifuga, which is found . Crossopteryx febrifuga. Rubiaceae. (G. Don.) Benth. Crossopteryx febrifuga (Paul Latham). Crossopteryx febrifuga flower and fruit (Paul. Latham). Preparations of Crossopteryx febrifuga (Afzel.) Benth. (Rubiaceae) are widely used in Northern Nigeria in the therapeutic management of.
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Antiulcerogenic activity of aescine in different experimental models.
Effect of the Crossopteryx febrifuga extract on piroxicam-induced gastric ulceration. In the first phase of the oral acute toxicity study, no remarkable signs of toxicity were observed in the rats. Relation to gastric hypermotility. Ethanol caused destruction of several glandular areas and focal infiltration of inflammatory cells into the sub mucosa areas. Histopathological studies febrifgua confirmed the extract’s mucosal protective effect croszopteryx that it inhibited both piroxicam – and ethanol induced mucosal atrophy, infilteration by eosinophils and lymphoplasma cells in the wall glandular destruction, focal infiltration of inflammatory cells into mucosa areas.
Flora of Zimbabwe: Species information: individual images: Crossopteryx febrifuga
Anti-ulcer drugs of plant origin. Several plants containing high amounts of saponins have been shown to possess antiulcer activity in several experimental bioassays Yamahara et al, ; Febriduga and Takaish, ; Morikawa et al, probably acting as an activator of mucus membrane protective factors Saito et al. Triterpene saponins with gastroprotective effects from tea seed the seeds of Fberifuga sinensis J Natural Products. The studies were carried out following the principles of good laboratory practice and animal handling National Institutes of Health Guide for the Care and use for Laboratory animals; Publication No.
Shows crossopferyx of mucosa layer of group treated with ethanol only Magnification X This observation further highlights the safety of the extract as an analgesic without gastrointestinal side effects associated with the traditional NSAIDs.
The technical assistance of the Staff febrlfuga Animal Facility center is highly appreciated. In conclusion this study illustrated the safety of Crossopteryx febrifuga in gastrointestinal tract when used as an antiinflammatory analgesic agent that could be developed for management of painful inflammatory disorders.
Histopathological studies of the rat stomach tissues were also carried out in order to determine its safety profile on the gastrointestinal tract git. Six hours after piroxicam administration, the rats in all the groups were sacrificed under diethyl ether anesthesia.
Cyclooxygenase-2 inhibition increases gastric tone and delays gastric emptying in rats. The choice of models used for antiulcer evaluation is very appropriate because the protocols undertaken in the rats are those mostly used for the evaluation of antiulcer agents and are reproducible.
The stem bark was cleaned, air-dried for seven 7 days and crushed into coarse powder using a pestle and mortar. A severe decrease in gastric mucosal blood flow has been reported after treatment with indomethacin Murai et al. These results showed that the extract had no deleterious effects and was cytoprotective on the gastrointestinal tract git. The cytoprotective effect of the extract may have been due to its ability to promote secretion of bicarbonate and production of mucus.
The number of deaths in each group within 24 h was recorded and the final LD 50 values were calculated as the geometric mean of the highest nonlethal dose with no deaths and the lowest lethal dose where deaths occurred. In the stomach, prostaglandins is critical for the maintenance of gastric mucosal integrity, but the mechanism involved in the cytoprotective action of prostaglandins is still incompletely understood.
Effect of the extract on piroxicam-induced gastric ulceration Piroxicam produced focal haemorrhagic gastric lesions and inflammation of the stomach mucosa in the rats. The results obtained from the study showed that the methanolic stem bark extract of Crossopteryx febrifuga possess anti-ulcerogenic activity in rats.
Crossopteryx febrifuga (Afzel. ex ) Benth. — The Plant List
Ulcer index UI defined as the severity of damage caused by an ulcer inducing agent was then calculated using the formula:. Table 2 Effect of the Crossopteryx febrifuga extract on piroxicam-induced gastric ulceration.
Structural requirements efbrifuga flavonoids for nitric oxide production inhibitory activity and mechanism of febrifuha. Studies by Santo et al. Pharmacological screening and toxicology. Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions.
These rats were approved for use by the AFC committee after reviewing the protocol. These rats were also observed for signs of toxicity and mortality for the first critical 4h and thereafter daily for febrifugaa days.
The rats were kept under the same conditions and observed for signs of toxicity which include but not limited to paw-licking, stretching, respiratory distress and mortality for the first critical 4h and thereafter daily for 7 days.
West African Plants
Acute toxicity LD50 study The oral median lethal dose LD 50 of the methanolic extract was determined in rats orally using Lorke’s method with modifications.
Stimulation of rat gastric mucosal leukotriene C4 formation by ethanol and effect of gastric protective drugs. However in African countries including Nigeria, indigenous herbal medicines are widely used for the management of painful inflammatory disorders, despite an apparent lack of scientific evidence for their quality, safety and efficacy Fennell et al.
Misoprostol a synthetic analogue of prostaglandin E1 completely protected the mucosal layer against piroxicam-induced lceration.
Author information Copyright and License information Disclaimer. Discussion The results obtained from the study showed that the methanolic stem bark extract of Crossopteryx febrifuga possess anti-ulcerogenic activity in rats.